Ibogaine is an alkaloid derived from the bark of a West African shrub called Tabernanthe iboga. Historically in Ghana the herb has found use in a traditional religion namely Bwiti as psycho-pharmacological sacrament.
Medicinal Use
It was only until a few decades ago that the potential of ibogaine (the plant’s active ingredient) against drug addiction and withdrawal was realized. Ibogaine has since then been widely used clinically in treating addiction and substance dependence. Ibogaine is perhaps the most widely studied alkaloid.
Pharmacology
Ibogaine acts by modifying the shape and function of neuron receptors involved in neurotransmission of molecules of abused drugs. Specifically, it modifies the opioid receptors in the brain hence modulating intracellular signaling in opioid dependent patients. Ibogaine also boosts the activity of morphine in the suppression of Adenylyl Cyclase (AC) to avoid AC activation which is characteristic in patients withdrawing from opioids.
Dosing
Dosing for Ibogaine ought to be determined specific patient health conditions and age and can best be decided upon by a healthcare professional.